One jab could protect you from flu for life
Saturday, January 5th, 2008
Virgil: We’ll all have come across flu at some point in our lives. Less commonly referred to as influenza, it is a dangerous virus that spreads during winter and causes as many as 1,000,000 deaths every year (4,000 in the UK). To combat this, most people are strongly encouraged to get an annual flu vaccination, and this demand sets drug companies into a manufacturing rush each winter. However, the problem for such companies is not so much the quantity as the quality of the drug; because the virus mutates over time, it needs to be constantly altered to fit the particular strain that is circulating.
It is for this same reason that people have to have the jab again and again to maintain immunity. This is of course expensive, as well as tedious for patients, resulting in many people simply not getting the jab at all. However a new vaccine produced by drug company Acambis hopes to be able to tackle all possible mutations of the most common form of the virus, Influenza A. The drug, appropriately named ACAM-FLU-A, works by targetting a particular protein named M2 that is present in all strains of flu. Previous drugs targetting different proteins showing up on only some of the strains.
In a limited human trial, 9 out of 10 patients developed lifelong immunity to flu, however Acambis scientists are now working to perfect the drug before larger human trials. Dr Michael Watson is very confident:
“As a universal vaccine, ACAM-FLU-A can potentially overcome many of the drawbacks of existing influenza vaccines. It can be manufactured at any time of the year, and could be stockpiled in advance of a pandemic or potentially used routinely to ensure population protection against future pandemics.”
It is the notion of a pandemic that scares most experts. Analysts claim that a pandemic of the human form of bird flu across the world is “inevitable”, and that when this arrives it could kill as many as 50,000,000 people. At this sort of scale, the “winter-only” drugs currently in use would be much less effective in stopping the virus, which would mutate as it moves around. But will the new lifelong jab prevent this kind of catastophe? Whilst it has the potential to immunise most of us to most types of flu we are likely to encounter, Professor Ian Jones, a virologist at the University of Reading, states that “larger trials and tests on a wider range of viruses will be needed before the full potential for pandemic protection can be assured.”







